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Study: Ibuprofen is best for kids with broken arms
2009-08-19
MILWAUKEE - Kids with a broken arm do better on a simple over-the-counter painkiller than on a more powerful prescription combination that includes a narcotic, a surprising study finds. It tested ibuprofen, sold as Advil, Motrin and other brands, against acetaminophen plus codeine -- a combo called Tylenol No. 3 that is also sold in generic form. The children on ibuprofen did better, said the study leader, Dr. Amy Drendel of the Medical College of Wisconsin in suburban Milwaukee. "They were more likely to play, they ate better and they had fewer adverse effects," she said. Results were published online Tuesday by the Annals of Emergency Medicine. Experts praised the study as one of the few to compare medicines that have been long used in children based on how they work in adults. "We want to start with what's effective and less likely to cause problems," and in this case, it turned out to be a cheap, over-the-counter drug, said Dr. Knox Todd, an emergency medicine pain researcher at Beth Israel Medical Center in New York and a member of the American Pain Society's board of directors. The results do not mean that ibuprofen beats acetaminophen for everyday pain relief in children or anyone else, though. The study tested a specific use -- pain in the first three days after a broken arm -- and the acetaminophen was combined with the narcotic codeine, not tested alone. Still, it shows the best way to treat a very common problem: As many as one out of five kids will break a bone before age 10 -- often, an arm. Researchers randomly assigned 336 children ages 4 to 18 to go home with liquid versions of either ibuprofen or the acetaminophen-codeine combo after being treated for a broken arm at Children's Hospital of Wisconsin. Neither the children, parents nor the doctors knew who received what treatment until the study ended. Full results were available on 244 children. The portion who failed to get relief from their assigned medicine was roughly the same. However, half of those on the combo medicine reported side effects -- mostly nausea and drowsiness that can occur with narcotics like codeine -- versus 30 percent of those given ibuprofen. The ibuprofen users also had fewer problems eating, playing, going to school or sleeping. They and their parents reported more satisfaction with the treatment. "A lot of emergency medicine physicians are afraid to give kids narcotics and a lot of parents are uncomfortable with narcotic medicine," so finding an effective alternative is good news, Drendel said. The hospital and medical school paid for the study, and a hospital-related charity paid for $10 Toys R Us gift certificates for each participant. The study has nothing to do with limits on Tylenol for adults that were recently proposed by an advisory panel to the federal Food and Drug Administration, said Todd, who is a member of that panel. "Acetaminophen when taken as directed is a very safe drug. The problem is people taking too much," or its inclusion in drugs that people might not be aware of, he explained. ___ On the Net: Annals of Emergency Medicine: http://www.annemergmed.com/
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